Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells

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Reversing effect and mechanism of soluble resistance-related calcium-binding protein on multidrug resistance in human lung cancer A549/DDP cells.

Lung cancer is the primary malignancy of the lung and is the leading cause of cancer‑associated mortality in China. Multidrug resistance (MDR) is an essential aspect of lung cancer treatment failure and a popular topic of investigation in tumor studies. Previous studies have demonstrated that soluble resistance‑related calcium‑binding protein (Sorcin) is involved in the MDR of various types of ...

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Multidrug resistance and the lung resistance-related protein in human colon carcinoma SW-620 cells.

BACKGROUND Lung resistance-related protein (LRP), the major vault protein in humans, is sometimes overexpressed in multidrug-resistant cells. Because cells transfected with the LRP gene did not express the multidrug-resistant phenotype, we investigated whether LRP is involved in multidrug resistance. METHODS SW-620 cells, a human colon carcinoma cell line, alone or transfected with an express...

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Nanodrug delivery in reversing multidrug resistance in cancer cells

Different mechanisms in cancer cells become resistant to one or more chemotherapeutics is known as multidrug resistance (MDR) which hinders chemotherapy efficacy. Potential factors for MDR includes enhanced drug detoxification, decreased drug uptake, increased intracellular nucleophiles levels, enhanced repair of drug induced DNA damage, overexpression of drug transporter such as P-glycoprotein...

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Lung resistance-related protein: determining its role in multidrug resistance.

Resistance to cytotoxic drugs remains a major obstacle for the successful treatment of cancer (1). Over the past two decades, a great deal of information has emerged that elucidates how cancer cells become drug resistant. At least one prominent drugresistance mechanism in cancer cells is the reduction of intracellular drug concentration at the putative drug target. There are at least two mechan...

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Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cells.

Lung cancer is a predominant cause of cancer-related mortality and numerous lung cancer patients succumb to the disease due to drug resistance. A number of microRNAs (miRNAs) are upregulated in cancer and are involved in tumorigenesis, functioning as oncogenes. Several functional studies have shown that miR-21 is important in carcinogenesis; however, none of these studies has investigated multi...

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ژورنال

عنوان ژورنال: Molecular Medicine Reports

سال: 2014

ISSN: 1791-2997,1791-3004

DOI: 10.3892/mmr.2014.2936